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Metolazone is used as the main active component belong to a group of medications known as diuretics. It is quinazoline-based sulfonamide thiazide-like, diuretic. It acts on the distal convoluted tubule and inhibits the sodium-chloride symporter so as to prevent the sodium and chloride reabsorption. It is a quinazoline diuretic, with properties similar to thiazide diuretics that play the role of a diuretic, an antihypertensive agent and anion transport inhibitor.

Class of Drugs – Diuretics

Molecular Formula – C16H16ClN3O3S

Molecular Weight – 365.8 g/mol

Working: This diuretic drug acts by blocking salt and fluid retention by the kidneys so as to increase the urinary output of salt and water. Metolazone is chemically related to the thiazide class of diuretics and works in a similar manner.

Uses: This water pill actively increases the amount of urine formed, which causes the body to get rid of excess water. Metolazone drug is approved for the treatment of high blood pressure. Reducing high blood pressure helps prevent strokes, heart attacks, and kidney problems. It also reduces swelling/fluid retention (edema) which can result from conditions like congestive heart failure or kidney disease. It also improves symptoms such as trouble breathing.

Popular Brands and Dosages: This is an effective medication used to treat high blood pressure. It is used in a popular brand medicine as mentioned below:

  • Zaroxolyn: 2.5 mg and 5 mg

Other health conditions like kidney disease, liver disease, untreated mineral imbalance, gout, lupus should be discussed with the doctor before consuming this medicine.