Generic Cuprimine


Manufacturer: Valeant Pharmaceuticals

Cuprimine is a chelating agent that binds to excess copper and removes it from the bloodstream. In certain conditions, excess copper can build up in the bloodstream, leading to tissue damage throughout the body. It is used to remove excess copper in people with an inherited condition called Wilson’s disease. Valeant Pharmaceuticals, one of the best pharmaceutical companies manufactures this medicine. It is composed in a conventional tablet form and available in a dosage of 250 mg.

SKU: Valeant Cuprimine Categories: ,

Available Options

Generic Cuprimine - 250mg

Pack SizePrice/unitPriceQtyAdd to cart
30 pills$0.68$20.40
60 pills$0.66$39.58
90 pills$0.63$56.92
120 pills$0.62$74.26
180 pills$0.61$108.94
240 pills$0.58$138.72


Active Ingredient

The main active component of this medicine is Penicillamine, which is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, the component with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, it induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. It is chelating agent used to decrease copper stores in Wilson disease. It is capable of causing hypersensitivity reactions, some of which are accompanied by liver injury which is typically cholestatic.


The given medication is used to treat rheumatoid arthritis, Wilson’s disease, and a certain disorder which causes kidney stones. For the treatment of rheumatoid arthritis, Cuprimine is known as a disease-modifying antirheumatic drug (DMARD). It helps to decrease pain/tenderness/swelling in the joints.

For the treatment of Wilson’s disease, this medicine binds to copper and helps it to be removed from the body. Decreasing copper levels helps to improve liver function and the mental/mood/nerve problems caused by the disease. For the treatment of cystinuria, penicillamine helps to decrease the amount of a certain substance in the urine which can cause kidney stones.

Action Mechanism

It may be related to reduction of collagen formation. Collagen is a type of tissue compound that forms as part of scar tissue that results from inflammation. This medicine also may result in suppression of the immune system.

In people with rheumatoid arthritis, Cuprimine appears to slow the progression of the disease and improve function. For this reason it is considered a disease modifying anti-rheumatic drug (DMARD). It binds copper, iron, mercury, lead, and cystine which then are excreted in the urine, and this mechanism is important in treating several non-rheumatic diseases including Wilson’s disease.


This medication is available for oral consumption and in dosage as mentioned below:

  • 250 mg: It is to be taken on an empty stomach 1 hour before or 2 hours after meals as directed by the doctor


This medicine is not approved to treat juvenile rheumatoid arthritis.


Can Cuprimine be used to treat other autoimmune diseases besides rheumatoid arthritis?

Cuprimine is primarily indicated for rheumatoid arthritis, Wilson’s disease, and cystinuria. While it may have immunosuppressive effects, it is not typically prescribed for other autoimmune conditions. Patients with other autoimmune diseases should consult their healthcare provider for appropriate treatment options.

How long does it take for Cuprimine to start working for rheumatoid arthritis?

The onset of action of Cuprimine in rheumatoid arthritis can vary from person to person. Some individuals may experience improvement in symptoms within a few weeks, while others may require several months of treatment before significant relief is achieved. It’s essential to continue taking Cuprimine as prescribed and follow up with your doctor regularly.

Are there any dietary restrictions while taking Cuprimine?

Patients taking Cuprimine should avoid foods high in copper, such as organ meats, shellfish, nuts, chocolate, and mushrooms. Consuming excessive copper-rich foods may counteract the medication’s effectiveness in treating Wilson’s disease. It’s important to follow a balanced diet and discuss any dietary concerns with your healthcare provider.

Can Cuprimine cause vision problems?

While rare, Cuprimine may rarely cause ocular side effects such as retinopathy or vision changes. Patients taking Cuprimine should undergo regular ophthalmologic examinations to monitor for any signs of eye problems. If you experience changes in vision or any other ocular symptoms, inform your doctor promptly.

Is it safe to drink alcohol while taking Cuprimine?

It is generally recommended to avoid alcohol while taking Cuprimine, as alcohol consumption may exacerbate certain side effects such as liver toxicity or gastrointestinal upset. Alcohol may also interact with Cuprimine, potentially affecting its effectiveness or increasing the risk of adverse reactions. See your healthcare provider for individual guidance.

Can Cuprimine be taken long-term?

Cuprimine may be prescribed for long-term use in patients with chronic conditions such as rheumatoid arthritis or Wilson’s disease. However, the duration of treatment and the need for continued therapy should be determined by your healthcare provider based on individual response and disease progression. Regular monitoring and follow-up appointments are essential for assessing treatment efficacy and safety.

Does Cuprimine interact with dietary supplements?

Yes, Cuprimine may interact with certain dietary supplements, particularly those containing minerals such as zinc or iron. These supplements may interfere with the absorption or effectiveness of Cuprimine. It’s important to inform your healthcare provider about all supplements you are taking to avoid potential interactions.

Can Cuprimine cause allergic reactions?

Yes, Cuprimine may rarely cause allergic reactions in some individuals, including skin rash, itching, or difficulty breathing. If you experience any signs of an allergic reaction, such as hives, swelling, or trouble breathing, seek medical attention immediately. Inform your healthcare provider about any known allergies before starting Cuprimine.

Can Cuprimine be used in children?

Cuprimine is not typically recommended for use in children, as safety and efficacy data in pediatric populations are limited. However, in certain cases of Wilson’s disease or other conditions, pediatric patients may receive Cuprimine under the supervision of a pediatric specialist. Consult a healthcare provider for appropriate treatment options for children.

How should Cuprimine be discontinued?

Discontinuing Cuprimine should be done gradually under the guidance of a healthcare provider to minimize the risk of disease flare-ups or withdrawal symptoms. Abruptly stopping Cuprimine may lead to worsening of symptoms or disease recurrence. Your doctor will provide instructions on tapering off the medication safely.

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