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  • Penicillamine, disease-modifying ant rheumatic drug that treats rheumatoid arthritis and a condition in which high levels of copper in the body cause damage to the liver, brain, and other organs
  • It helps to decrease pain/tenderness/swelling in the joints and decreases the copper level that improves liver function and the mental/mood/nerve problems
  • Penicillamine is an active ingredient used in popular brands like, Cuprimine
  • The medicine is available in the dosage Penicillamine 250 mg
  • Medicine is composed as white capsule and packed as 10 capsules per blister
  • Effectiveness can be seen in 2 to three months

Directions for Use

It is advisable to take Penicillamine on an empty stomach usually 1 or 2 hours before meals, as instructed by the doctor

Do’s and Don’ts

  • Advisable to maintain a gap of an hour with medications if consuming
  • Operating machinery or driving should be avoided after consumption of Cuprimine
  • Blood sugar should be monitored and discussed regularly with the doctor time to time
  • Vaccinations during your treatment with Penicillamine strictly prohibited unless directed by the doctor
  • Capsules should be swallowed as whole

Side Effects

  • Common side effects: Signs of infection such as fever, persistent sore throat, swollen lymph nodes, easy bruising/bleeding, unusual tiredness, rapid breathing, skin blisters, mouth sores, new or worsening joint pain, thinning/wrinkling skin
  • Serious side effects: Kidney problems like change in the amount of urine, bloody urine), coughing up blood, shortness of breath, muscle weakness, eye problems, persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, yellowing eyes/skin


  • Allergic reaction like rashes, itching/swelling, severe dizziness, and trouble breathing are rare, contact the doctor if occur
  • Recommended to discuss about medical history of liver disease, kidney disease, lung disease, alcohol use, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal disease, any active infection, folic acid deficiency before treating with Cuprimine
  • Severe drowsiness/dizziness or breathing problems can occur if overdosed the medicine
  • Penicillamine is not safe for pregnant and breastfeeding women, it may harm unborn or nursing baby


  • Store Penicillamine in away from the reach of children and pets
  • Put Penicillamine in the medical box in its original container
  • Avoid storing Cuprimine in the bathroom, excess moisture can harm the medicines


  • Avoid throwing Cuprimine in the household dustbin without sealing in the bag
  • Do not dispose the medicine on the junk heap
  • Dispose Penicillamine with undesirable substances