Leflunomide medication is an immunomodulatory agent used to treat rheumatoid arthritis and psoriatic arthritis. This component is a monocarboxylic acid amide obtained by formal condensation of the carboxy group. It plays the role of a non-steroidal anti-inflammatory drug, an antineoplastic agent, an antiparasitic agent, a hepatotoxic agent, a prodrug, a pyrimidine synthesis inhibitor, and an immunosuppressive agent. It also acts as a tyrosine kinase inhibitor.

Class of Drugs – Anti-rheumatic drugs

Molecular Formula – C₁₂H₉F₃N₂O₂

Molecular Weight – 270.21 g/mol

Working: This ingredient decreases the inflammation by suppressing the activity of immune cells leads to the inflammation. It also suppresses immune cells by inhibiting dihydroorotate dehydrogenase, an enzyme that is important for the production of DNA and RNA. It cannot multiply or function since it has a unique and different mechanism of action. It can be used with other medications to treat rheumatoid arthritis

Uses: This active ingredient is used in medicines that treat rheumatoid arthritis. RA is a condition in which the body’s defense system fails to recognize the body as itself, it attacks the healthy tissues around the joints. This pill helps to reduce the joint damage/pain/swelling caused due to the condition. It helps to move better. Leflunomide weakens the immune system and decreases swelling. It belongs to a group of medicines known as an anti-rheumatic class of drugs. It also helps to reduce joint damage and improves physical functioning.

Popular Brands and Dosages: This anti-rheumatic ingredient Leflunomide is used in a popular brand as mentioned below:

• Arava: 10 mg and 20 mg

It should be taken with or without food as mentioned in the prescription by the doctor.