Enalapril Maleate / Hydrochlorothiazide is a combination of two active ingredients used as the main active component in the medicines. Enalapril Maleate is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It blocks the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is primarily excreted by the kidneys. This component is diuretic used for the treatment of hypertension and congestive heart failure.
Class of Drugs – ACE inhibitors + thiazide diuretic
Molecular Formula – C24H32N2O9 + C7H8ClN3O4S2
Molecular Weight – 492.5 g/mol + 297.7 g/mol
Working: This combination Enalapril Maleate / Hydrochlorothiazide acts by blocking salt and water reabsorption in the kidneys so as to lead increased urine output (diuresis). It shows its action by lowering high blood pressure. The combination reduces blood pressure better than either drug alone.
Uses: This medication is approved for the treatment of high blood pressure i.e. hypertension. It decreases the high blood pressure that helps prevent strokes, heart attacks, and kidney problems. This product contains 2 active components, Enalapril Maleate / Hydrochlorothiazide. Enalapril belongs to a class of drugs known as ACE inhibitors, which work by relaxing blood vessels so that blood can flow through the body more easily. Hydrochlorothiazide is a diuretic, which causes the body to get rid of extra salt and water. It increases the amount of urine produced while initiating the medication.
Popular Brands and Dosages: This combination is sued in popular brand medicines as mentioned below;
- Vaseretic: 5 mg + 12.5 mg and 10 mg + 25 mg
- Capozide:5 mg + 12.5 mg and 10 mg + 25 mg
- Accuretic:5 mg + 12.5 mg and 10 mg + 25 mg
- Zestoretic:5 mg + 12.5 mg and 10 mg + 25 mg
Do not operate machinery or drive a car immediately after the administration of this medicine.