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Losartan Potassium-Hydrochlorothiazide

[ Generic Medicines for High Blood Pressure Treatment ]

Losartan Potassium / Hydrochlorothiazide is a combination of two active ingredients. Losartan Potassium is a non-peptide angiotensin II receptor antagonist that shows antihypertensive activity. It works by binding to the angiotensin II receptor and blocking the binding of angiotensin II to the receptor. It promotes vasodilatation and counteracting the effects of aldosterone. Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It is a metabolite that binds to and accumulates in red blood cells. It is primarily excreted by the kidneys.

Class of Drugs – Angiotensin receptor blockers + Diuretics

Molecular Formula – C22H22ClKN6O + C7H8ClN3O4S2

Molecular Weight - 461 g/mol + 297.7 g/mol

Working: One of the components in the medication Losartan Potassium / Hydrochlorothiazide, Losartan is an angiotensin II receptor blocker that blocks the action of angiotensin II, a chemical in the body that causes the blood vessels to tighten and narrow. It helps to relax and widen the blood vessels, which lowers blood pressure.

Hydrochlorothiazide is a thiazide diuretic that removes excess salt and water from the body. This keeps the heart from working as hard to pump blood, which lowers the blood pressure.

Uses: Mentioned medication is indicated for the treatment of high blood pressure. It is also used to lower the risk of strokes in people with high blood pressure and an enlarged heart. Reducing high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication contains two medications i.e. losartan and hydrochlorothiazide. Losartan Potassium / Hydrochlorothiazide is a combination of an angiotensin receptor blocker and diuretics. It relaxes blood vessels so that blood can flow more easily and diuretic causes the formation of more urine, which helps the body get rid of extra salt and water.

Popular Brands and Dosages: This combination of drugs is used in a popular brand medicine as mentioned below:

  • Hyzaar: 50 mg + 12.5 mg

Do not consume this medicine without consulting the doctor.