Irbesartan-Hydrochlorothiazide is a combination of two active components. Irbesartan is a nonpeptide angiotensin II antagonist that has antihypertensive activity. It blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by the adrenal cortex, which reduces the excretion of sodium and increases the excretion of potassium. Angiotensin II also works as a vasoconstrictor in vascular smooth muscle.

Hydrochlorothiazide is a short-acting thiazide diuretic that is widely indicated to treat hypertension and edema. This agent’s metabolite appears to preferentially bind to and accumulate in red blood cells.

Class of Drugs – Nonpeptide angiotensin II antagonist + Thiazide diuretic

Molecular Formula – C₂₅H₂₈N₆O + C₇H₈ClN₃O₄S₂

Molecular Weight – 428.5 g/mol + 297.7 g/mol

Working: This mediation is an angiotensin receptor blocker that works by relaxing blood vessels so that blood can flow more easily. Another ingredient is a water pill that causes you to produce more urine, which helps the body get rid of extra salt and water. Irbesartan-Hydrochlorothiazide is to be used for a condition of heart failure.

Uses: Given medication is indicated to treat high blood pressure. Decreasing high blood pressure helps prevent strokes, heart attacks, and kidney problems. It has two medications i.e. irbesartan and hydrochlorothiazide. It is a combination of an angiotensin receptor blocker that works by relaxing blood vessels so that blood can flow more easily and Hydrochlorothiazide, which is a water pill that causes you to make more urine, which helps your body get rid of extra salt and water.

Popular Brands and Dosages: The combination of Irbesartan-Hydrochlorothiazide medication is used as the main active component in a popular brand medicine as mentioned below:

• Avalide:  150 mg + 12.5 mg, 300 mg + 12.5 mg, and 300 mg + 25 mg

Severe sweating, diarrhea, or vomiting can increase the risk of lightheadedness or a serious loss of body water. It is advisable to consume more fluids or water than usual.