Spironolactone-Hydrochlorothiazide is a combination of two ingredients and effectively used to treat high blood pressure. Spironolactone is a corticosteroid with a potassium-sparing diuretic, antihypertensive, and antiandrogen activities. It inhibits adrenocortical hormone aldosterone activity in the renal tubules, myocardium, and vasculature. It also inhibits the pathophysiologic effects of aldosterone formed in excess by various types of malignant and benign tumors. Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. Its metabolites to preferentially bind to and accumulate in red blood cells. This component is primarily excreted by the kidneys. It can be used to treat hypertension and congestive heart failure.

Class of Drugs – Aldosterone receptor antagonists and water pill

Molecular Formula – C₂₄H₃₂O₄S + C₇H₈ClN₃O₄S₂

Molecular Weight – 416.6 g/mol + 297.7 g/mol

Working: This mentioned a combination of components used in the treatment of high blood pressure. Spironolactone is in a class of medications called aldosterone receptor antagonists that causes the kidneys to eliminate extra water and sodium from the body into the urine. It reduces the loss of potassium from the body. Hydrochlorothiazide is a diuretic i.e. water pill used to get rid of extra salt and water from the body.

Uses: This medication is indicated to treat high blood pressure i.e. hypertension, heart failure, or extra fluid in the body or edema. Reducing high blood pressure prevents strokes, heart attacks, and kidney problems.

Spironolactone / Hydrochlorothiazide causes the body to get rid of extra salt and water. Its effects help to relax the blood vessels to form the blood flow easy. It increases the amount of urine produced after first consuming this drug. It helps to treat or prevent low blood potassium levels and block the activity of a certain natural substance that can cause edema.

Popular Brands and Dosages: This combination of active ingredients are used in a popular brand medicine as follows:

• Aldactazide: 25 mg + 25 mg

In case already taking medications to lower cholesterol like cholestyramine or colestipol, take Spironolactone / Hydrochlorothiazide at least 4 hours before or at least 4 to 6 hours after these medications.