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Trihexyphenidyl Hydrochloride is used as the main active ingredient in various medications to treating Parkinson’s disease. It is the hydrochloride salt form of trihexyphenidyl, synthetic, substituted piperidine that shows parasympatholytic activity. This active component antagonizes activities of acetylcholine through muscarinic receptors. It balances the cholinergic and dopaminergic activity in the basal ganglia that result in an improvement of classic Parkinson’s symptoms. It improves rigidity and tremor.

Class of Drugs – Anticholinergics

Molecular Formula – C20H32ClNO

Molecular Weight – 337.9 g/mol

Working: Given medicine belongs to a class of drugs called anticholinergics. Trihexyphenidyl Hydrochloride is supposed to act by restricting the function of a certain part of the nervous system that regulates body movements. It also helps relax certain muscles and makes movement trouble-free.

Uses: This medicine is indicated for the treatment of symptoms of Parkinson’s disease or involuntary movements due to the side effects of certain psychiatric drugs. It also acts as the antipsychotic medication such as chlorpromazine/haloperidol. It can stop severe muscle spasms of the back, neck, and eyes that are caused by psychiatric drugs. This pill can also reduce other side effects such as muscle stiffness/rigidity. Trihexyphenidyl Hydrochloride is not recommended for the treatment of movement problems caused by tardive dyskinesia.

Popular Brands and Dosages: This medicine is used in medicines of popular brands. Some of them are mentioned below:

  • Artane: 2 mg and 5 mg
  • Trihexy: 2 mg and 5 mg
  • Trihexane: 2 mg and 5 mg

This medication is contraindicated in people with narrow-angle glaucoma.