[ Generic Medicines for Cancer Treatment ]
Temozolomide is a medicinal drug, which is a triazene analog of dacarbazine with antineoplastic activity. It acts as a cytotoxic alkylating agent, which is converted at physiologic pH to the short-lived active compound, monomethyl triazine imidazole carboxamide. This cytotoxicity of MTIC is primarily to methylation of DNA at the O6 and N7 positions of guanine results in the inhibition of DNA replication. It is an active component is metabolized to MITC at all sites.
Class of Drugs – Alkylating agents
Molecular Formula – C6H6N6O2
Molecular Weight - 194.15 g/mol
Working: This active component belongs to a class of drugs called Alkylating agents acts by restricting cancer cells from forming DNA. DNA stands for Deoxy-ribose-Nucleic Acid. Temozolomide is the genetic material of a cell. When cancer cells are unable to produce DNA, they can't split into 2 new cells, so cancer stop growing.
Uses: This drug is indicated to treat certain types of brain cancer. Temozolomide is an alkylating agent that by slowing or stopping the growth of cancer cells. It is approved for the treatment of certain types of brain tumors.
Popular Brands and Dosages: This alkylating agent medication is used in the popular brand medicine as given below:
- Temodar: 20 mg, 100 mg, and 250 mg
Avoid having immunizations/vaccinations without the consent of the doctor. Do not contact people who have recently received live vaccines like flu vaccine inhaled through the nose.