Gefitinib is a medicine, which is an anilino quinazoline that shows the activity of antineoplastic. It works by inhibiting the catalytic activity of numerous tyrosine kinases that includes the epidermal growth factor receptor. It might be the result of inhibition of tyrosine kinase-dependent tumor growth. This active factor competes with the binding of ATP to the tyrosine kinase domain of EGFR so as to inhibit the receptor autophosphorylation. It leads to inhibition of signal transduction. It is available in the form of a conventional tablet.
Class of Drugs – A Protein Kinase Inhibitor
Molecular Formula – C22H24ClFN4O3
Molecular Weight – 446.9 g/mol
Working: This above medication is a protein kinase inhibitor. The active component Gefitinib is approved for the treatment of lung cancer. This drug acts by slowing or restricting the growth of cancer cells. It also helps blocks a certain protein i.e. an enzyme called tyrosine kinase.
It is a type of targeted cancer drug; tyrosine kinase is a protein that sends signals approaching cancer cells to grow. It promotes the blocking of these signals. The cancer cells need to have receptors for a protein called epidermal growth factor so that this component can work.
Uses: This particular drug is indicated for the treatment of lung cancer. It helps to slow or stop the growth of cells causing cancer. Its action mechanism is to block or inhibit the enzyme called tyrosine kinase.
Popular Brands and Dosages: This cancer-treating drug Gefitinib is used as the main active agent in a popular brand medicine as mentioned below:
- Iressa: 250 mg
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