Zidovudine-Lamivudine is a combination of two ingredients Zidovudine and Lamivudine. Zidovudine inhibits DNA polymerase, leads to the inhibition of DNA replication and cell death. This active component decreases levels of available pyrimidines. It is a nucleoside analog and reverses transcriptase inhibitor used in the therapy and prophylaxis of the human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS).
Lamivudine is used against the hepatitis B virus and HIV. It is phosphorylated to its active metabolites. In HBV, with L-MP into viral DNA by HBV polymerase leads to DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase.
Class of Drugs – Antiviral Drugs
Molecular Formula – 267.24 g/mol + 229.26 g/mol
Molecular Weight – C10H13N5O4 + C8H11N3O3S
Working: This combination of lamivudine and zidovudine components is indicated along with with other drugs to treat human immunodeficiency virus (HIV) infection. Zidovudine / Lamivudine are in a class of drugs known as nucleoside reverse transcriptase inhibitors. This active component work by reducing the amount of HIV in the blood.
Uses: This combination of two active medicines to help control HIV infection. This medicine helps to reduce the amount of HIV in the body so your immune system can work better. Zidovudine / Lamivudine lowers the risk of getting HIV complications like new infections, cancer and improves the quality of life.
Popular Brands and Dosages: This medicine is available in a dosage as mentioned below:
- Combivir: 150 mg + 300 mg
It may develop lactic acidosis, a dangerous build-up of lactic acid in the blood. Seek the doctor help in case experienced unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.