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Probenecid

[ Generic Medicines for Gout Treatment ]

Watson Benemid

Probenecid is a medicinal drug, which is a benzoic acid derivative with the anti-hyperuricemic property. This is used as the main active component in the medication for the prevention of gout and gouty arthritis. It inhibits the active reabsorption of urate at the proximal tubule in the kidney to increasing urinary excretion of uric acid and lowering serum urate concentrations. This medication also prevents urate deposition and promotes the resolution of existing urate deposits. This active component modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, so as to increase the drug serum concentration.

Class of Drugs – Uricosurics

Molecular Formula – C13H19NO4S

Molecular Weight - 285.36 g/mol

Working: This medication belongs to a class of drugs called uricosurics. It lowers high levels of uric acid in the body by helping the kidneys to get rid of uric acid. Lowering uric acid levels may also help the kidneys. Probenecid works by reducing the kidneys' ability to remove the antibiotic from the body. This drug should not be used in children younger than 2 years.

Uses: Given an effective drug is intended to prevent gout and gouty arthritis. This will not treat a sudden/severe attack of gout and may make it worse. Probenecid is a uricosuric that lowers high levels of uric acid in the body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Reducing uric acid levels may also help the kidneys. This drug can be taken in combination with certain antibiotics to increase the levels of antibiotic in the blood, which helps the antibiotics work better.

Popular Brands and Dosages: This medication is used as the active ingredient in a popular brand medicine as given below:

  • Benemid: 500 mg

This drug should not be used in case of a history of uric acid kidney stones, a gout attack that has already started, or a blood cell disorder.