Generic Benemid

Description

Active Ingredient

The active component of this medicine is Probenecid, which is a benzoic acid derivative with the anti hyperuricemic property. It inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing the urinary excretion of uric acid and lowering serum urate concentrations. It also prevents urate deposition and promotes the resolution of existing urate deposits. In addition, the component modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, to increase the drug serum concentration.

Indications

This medication is used to prevent gout and gouty arthritis. Benemid will not treat a sudden/severe attack of gout and may make it worse. It belongs to a class of drugs known as uricosurics. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Lowering uric acid levels may also help your kidneys. It increases the levels of antibiotics in the blood, which helps the antibiotics work better.

Action Mechanism

Probenecid-composed Benemid medicine is an oral drug used for reducing blood uric acid levels in patients with hyperuricemia and High uric acid can cause attacks of gout and kidney stones. It prevents attacks of gout by reducing uric acid levels in the blood. It does this by preventing the reabsorption of uric acid by the kidney and increasing its excretion from the body in the urine. This drug blocks excretion by the kidney of penicillin and related antibiotics and is used for increasing the levels of the antibiotics in the blood and increasing their effectiveness when treating infections.

Serious Side Effects

• Worsening gout symptoms
• Nausea
• Vomiting
• Severe pain in your side or lower back
• Blood in your urine
• Urine that looks cloudy or foamy
• Puffy eyes
• Stomach pain
• Swelling
• Painful or difficult urination
• Swelling in your ankles or feet
• Weight gain
• Pale or yellowed skin.

What other drugs will affect Benemid?

• Acetaminophen (Tylenol)
• Lorazepam
• Methotrexate
• Rifampin
• A sulfa drug
• An NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve).

Alternatives Of Benemid

• Generic Uloric
• Generic Colcrys
• Generic Zyloprim

What is Benemid used for?

This medicinal drug is used to prevent gout and gouty arthritis. It’ll not treat a sudden/excessive assault of gout and can make it worse. Probenecid belongs to a class of medicine known as uricosurics. It lowers the high stages of uric acid to your body by using supporting the kidneys to cast off uric acid.

What are the interactions with Benemid?

Some products that may interact with this drug include

• Cancer chemotherapy
• Baricitinib
• Dyphylline
• Ketorolac
• Methotrexate
• Pyrazinamide
• Salicylates
• Zidovudine
• Ceftazidime/avibactam
• Dapsone
• Heparin
• Fosfomycin

Dosages

This medication is available for oral consumption and in dosage as mentioned below:

• 500 mg: This tablet shall be taken twice a day with food or antacids to reduce stomach upset or as directed by the doctor

Note

This medicine should not be used in children younger than 2 years.