Colchicine is an active ingredient used in different medicines that treats a condition like gout. It is an alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. This active component binds to tubulin, through interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This results in an inhibition of the migration of leukocytes and other inflammatory cells. It reduces the inflammatory response to deposited urate crystals.
Class of Drugs – Anti-gout drugs
Molecular Formula – C22H25NO6
Molecular Weight – 399.4 g/mol
Working: This active ingredient Colchicine decreases the swelling and minimizes the buildup of uric acid crystals that cause pain in the affected joints. This component also prevents attacks of pain in the abdomen, chest, or joints mainly caused by an inherited disease like a familial Mediterranean fever. It is believed that it works by decreasing the body’s production of a certain protein. These proteins build up in people with familial Mediterranean fever. This mentioned active ingredient is not a medicine for pain so it should not be taken to treat other causes of pain.
Uses: This active component is used to prevent or treat gout attacks or flares. The condition of Gout is caused by excessive uric acid in the blood. Due to high uric acid levels in the blood, it may form hard crystals in the joints. This medication decreases swelling and reduces the building up of uric acid crystals that cause pain in the affected joints.
Popular Brands and Dosages: This active ingredient Colchicine is available in popular brands as follows:
- Colcrys: 0.5 mg and 0.6 mg
- Mitigare: 0.5 mg and 0.6 mg
- Gloperba: 0.5 mg and 0.6 mg