Methotrexate Sodium is an antimetabolite with antineoplastic and immunomodulating properties. This is an active component that binds to and inhibits the enzyme dihydrofolate reductase, leads to inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. The active ingredient acts by exhibiting the potent immunosuppressant properties. It is an organic sodium salt that is the disodium salt of methotrexate. Plays the role of dihydrofolate reductase inhibitor.

Class of Drugs – Antimetabolites

Molecular Formula – C₂₀H₂₀N₈Na₂O₅

Molecular Weight – 498.4 g/mol

Working: This mentioned medication works uniquely to treat each condition. It works by making it harder for the body to repair DNA. Cells in the body that grow rapidly react to this effect. This medication harms cancer cells when they grow more than normal cells.

When this medication used to treat psoriasis, it works by slowing down how fast the top layer of the skin is produced. Methotrexate Sodium helps to treat the symptoms of psoriasis.

While treating rheumatoid arthritis, it affects the immune system. This drug may help reduce pain, swelling, and stiffness from RA.

Uses: This medication is approved for the treatment of a certain type of cancer or to control severe psoriasis or rheumatoid arthritis. This drug can also be used to control juvenile rheumatoid arthritis. This medication belongs to a class of drugs known as antimetabolites. It acts by slowing or stopping the growth of cancer cells and suppressing the immune system.

Methotrexate Sodium can also help to reduce further joint damage and to preserve joint function.

Popular Brands and Dosages: It is used in the popular brand medicines as given below:

• Trexall: 2.5 mg and 10 mg

Medications composed with the mentioned active component may pass through the skin or breast milk. Consumption of this medicine is contraindicated in nursing mothers; it may harm a nursing infant.