[ Generic Medicines for Alcohol Dependence Treatment ]
Disulfiram is a bioavailable carbamoyl derivative and a proteasome inhibitor used in the treatment of alcoholism, with potential antineoplastic and chemosensitizing activities. It has a strong ability to chelate metals and its antineoplastic activity which is highly dependent upon binding to copper, a metal that selectively accumulates in cancer cells. These elements generate reactive oxygen species and inhibit proteasome activity, leading to an accumulation of ubiquitinated proteins. These processes lead to the induction of apoptosis. It inhibits various cancer-specific pathways results in inhibition of tumor cell growth.
Class of Drugs – Proteasome inhibitor
Molecular Formula – C10H20N2S4
Molecular Weight - 296.5 g/mol
Working: When alcohol is consumed, it is converted into acetaldehyde in the body by an enzyme called alcohol dehydrogenase. Another enzyme called acetaldehyde dehydrogenase then converts acetaldehyde into acetic acid. Disulfiram prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, so as to a buildup of acetaldehyde levels in the blood.
Uses: Proteasome inhibitor medicine Disulfiram is approved along with counseling and support to stop alcoholism. This active component blocks the processing of alcohol in the body. This causes a bad reaction when consume or drink alcohol.
Popular Brands and Dosages: Given active component is used in popular brand medicines as mentioned below:
- Antabuse: 500 mg
- Campral: 500 mg
- Revia: 500 mg
Avoid all alcoholic beverages or alcohol-containing products/foods such as cough and cold syrups, mouthwash, aftershave, sauces, vinegars while consuming this medication and for 2 weeks after stopping the medication.