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Sofosbuvir / Velpatasvir is a combination of two ingredients used to treat chronic hepatitis C.  Sofosbuvir is potent inhibitor of the hepatitis C virus used in combination with other antiviral agents to treat chronic hepatitis C. The treatment can cause reactivation of hepatitis B in some people coinfected with the hepatitis B virus.

Velpatasvir is an inhibitor of the hepatitis C virus, non-structural protein 5A replication complex that has potential activity against HCV genotypes 1-6. This active medication appears to bind to a domain I of the NS5A protein. This inhibits the activity of the NS5A protein and leads to the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication.

Class of Drugs – Antiviral Drugs

Molecular Formula – C22H29FN3O9P + C49H54N8O8

Molecular Weight – 529.5 g/mol + 883 g/mol

Working: This medication work by reducing the amount of hepatitis C virus in the body. Due to reduction of viruses in the body the immune system fight with the infection. Sofosbuvir / Velpatasvir helps the liver to recover. Chronic hepatitis C infection can develop serious liver problems like scarring, or cirrhosis, or liver cancer.

Uses: This particular combination of medications is used to treat chronic hepatitis C, which is a long-lasting infection. It is a viral infection of the liver. Sometimes this drug can be used with another antiviral medication. Sofosbuvir / Velpatasvir reduces the level of hepatitis C virus in the body, which make immune system strong to fight the infection and liver to recover.

Popular Brands and Dosages: This mentioned combination of two ingredients used in a popular brand medicine as given below:

  • Epclusa: 400 mg + 100 mg

Antacids lower the absorption of this drug. Keep the gap of at least 4 hours before or 4 hours after the administration of this drug.