Amantadine is a tricyclic amine with antiviral, antiparkinsonian, and anti-hyperalgesia activities. This is used as an active component that appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein. It is for the prevention of the release of infectious viral nucleic acids into host cells. It also prevents virus assembly during virus replication. It exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. It may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid receptor-mediated stimulation of acetylcholine, resulting in anti-hyperalgesia.
Class of Drugs – Antivirals
Molecular Formula – C10H17N
Molecular Weight – 151.25 g/mol
Working: This medication belongs to a group of drugs called antivirals. This is not fully understood how amantadine works as an antiviral or anti-Parkinson’s disease drug. Amantadine blocks the multiplying of influenza A virus in the body. In people with Parkinson’s disease and drug-induced movement disorders, it increases the effect of a chemical in the brain called dopamine. It helps the body better control the movements.
Uses: Given medication is approved to treat Parkinson’s disease. This drug is also used to treat certain movement disorders caused by some drugs. Amantadine is thought to work by restoring the balance of certain natural substances in the brain.
Popular Brands and Dosages: This medication is an antiviral medicine is used as the main active component in a popular brand medicine as mentioned below:
- Symmetrel: 100 mg
Do not receive a nasal flu vaccine while treating with this medicine, and for at least 48 hours after the last dose.