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Ezetimibe-Simvastatin

[ Generic Medicines for High Cholesterol Treatment ]

Ezetimibe / Simvastatin is a combination of two active ingredients used to treat high cholesterol. Ezetimibe is a cholesterol absorption inhibitor with a lipid-lowering activity that inhibits the intestinal absorption of cholesterol and related phytosterols. It causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Simvastatin inhibits hepatic hydroxymethyl-glutaryl coenzyme reductase. It lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.

Class of Drugs – Statins

Molecular Formula – ‎C24H21F2NO3 + ‎C25H38O5

Molecular Weight - 409.4 g/mol + 418.6 g/mol

Working: The active component in the medication ezetimibe lowers blood cholesterol by blocking the absorption of cholesterol, such as dietary cholesterol, from the intestine. It does not work to affect the absorption of triglycerides. Other active component simvastatin belongs to a class of drugs called HMG-CoA reductase inhibitors, called statins that reduce cholesterol by blocking an enzyme in the liver, which makes cholesterol.

Uses: This combination medication Ezetimibe / Simvastatin is indicated for the treatment of high cholesterol along with a proper diet. It helps lower bad cholesterol and fats like LDL, triglycerides. It also helps raise good cholesterol in the blood. The medicine reduces the amount of cholesterol the body absorbs from the diet. It also decreases cholesterol levels produced by the liver.

Popular Brands and Dosages: This combination of medication Ezetimibe / Simvastatin is used in popular brand medicines as mentioned below:

  • Vytorin: 10 mg + 10 mg and 10 mg + 20 mg
  • Lipitor: 10 mg + 10 mg and 10 mg + 20 mg
  • Zetia: 10 mg + 10 mg and 10 mg + 20 mg
  • Crestor: 10 mg + 10 mg and 10 mg + 20 mg

Recommended to consume a proper diet includes a low-cholesterol/low-fat diet, other changes in lifestyle may help work better include exercising, losing weight if overweight, and stopping smoking.