Active Ingredient: Mercaptopurine is an active component that has antineoplastic and immunosuppressive activities. This medication is made through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase, mercaptopurine metabolites 6-thioguanine-5′-phosphate, and 6-this inosine monophosphate. This inhibits the nucleotide interconversions and de novo purine synthesis to block the formation of purine nucleotides and inhibiting DNA synthesis. Additionally, this active component is converted to 6-methylmercaptopurine ribonucleotide by 6-thiopurine methyltransferase and MMPRs are also potent inhibitors of de novo purine synthesis.
Indications: This medication belongs to a group of drugs known as purine antagonists. This drug is indicated for the treatment of a certain type of cancer such as acute lymphocytic leukemia. Purinethol is a chemotherapy drug that slows or stops the growth of cancer cells.
Consult the doctor before giving this drug to young or children, it may show some severe side effects.
Action Mechanism: Given the chemotherapy drug works by slowing or restricting the growth of cancer cells. This drug Purinethol can be used to treat Crohn’s disease, ulcerative colitis, and lymphoblastic lymphoma
Dosages: This chemotherapy drug is available in a conventional tablet form for oral consumption as mentioned below:
- 50 mg: This tablet is advised to be taken with or without as exactly mentioned in the prescription by the doctor
Note: In case of an experienced upset stomach, throwing up, diarrhea, or are not hungry, immediately seek help from the doctor. This medication is not recommended in women who are pregnant or breastfeeding a baby. It may harm the unborn baby or nursing infant.