Generic Hydrea

Description

Active Ingredient

The active component of this medicine is Hydroxyurea. This ingredient is a mono hydroxyl-substituted urea antimetabolite that inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates. It acts to prevent the cells from leaving the G1/S phase of the cell cycle. It exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive phase and replicating with DNA repair.

The active component is an antimetabolite used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease. It is related to a low rate of transient serum enzyme and bilirubin elevations during therapy.

Indications

This medication is indicated in people with sickle cell anemia to reduce the number of painful crises. This condition is caused by the disease and reduces the need for blood transfusions. Hydrea can also be used to treat certain types of cancer like chronic myelogenous leukemia and squamous cell carcinomas.

Action Mechanism

The active component Hydroxyurea is also called Hydroxycarbamide. This ingredient is converted to a free radical nitroxide in vivo, and transferred by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme.

Side Effects

• Hematological Disorder
• Gastrointestinal Disorder
• Eating Disorder
• Loss Of Appetite

Dosages

This mentioned medication Hydrea is composed as a capsule for oral consumption and made available in a dosage as given below:

• 500 mg: It is indicated for oral administration once a day with or without food as directed by the doctor.

Note

This medication can be absorbed through the skin and lungs, pregnant or nursing women should not handle this medication or breathe the dust from the capsules.

FAQs

What is Hydrea?

Hydrea is the brand name for the medication Hydroxyurea. It’s a prescription drug primarily used in the treatment of certain cancers and blood disorders. Hydroxyurea works by slowing down the growth of abnormal cells in the body.

What is Hydrea used for?

Hydrea is commonly prescribed for conditions such as chronic myelogenous leukemia (CML), certain types of melanoma, and sickle cell anemia. For sickle cell disease, it helps reduce the frequency of painful crises and the need for blood transfusions.

What are the side effects of Hydrea?

Common side effects include nausea, vomiting, diarrhea, loss of appetite, mouth sores, and skin changes (like darkening or reddening). More severe side effects may include bone marrow suppression, leading to low blood cell counts, and an increased risk of developing secondary cancers.

Foods to avoid when taking Hydroxyurea?

When taking Hydroxyurea, it’s advised to avoid foods high in purines, like organ meats and certain types of fish. Alcohol should also be limited. A balanced diet and staying hydrated can help manage potential side effects.

What happens if you stop taking Hydroxyurea?

Do not stop taking Hydroxyurea suddenly without consulting your healthcare provider, as it could worsen your condition or lead to a rebound effect. Your doctor will provide guidance on safely discontinuing the medication if necessary.

How long can you take Hydroxyurea?

The duration of treatment varies depending on the condition and individual response. Some may need it for a short period, while others may require long-term or lifelong treatment. Your doctor will determine the appropriate duration based on your specific circumstances.

What is the cost of Hydrea?

The cost of Hydrea can vary based on dosage, formulation, and location. Insurance coverage and financial assistance programs may affect out-of-pocket costs. Check with your pharmacist or healthcare provider for accurate pricing and explore options for assistance if needed.

Are there any precautions or warnings associated with Hydrea use?

Hydrea may increase the risk of developing certain serious conditions, such as secondary leukemia or skin cancer. Regular monitoring and follow-up with your healthcare provider are important while taking this medication.

Does Hydrea affect fertility in men and women?

Hydrea may affect fertility in both men and women. It’s important to discuss fertility preservation options with your healthcare provider before starting treatment if you plan to have children in the future.