Generic Sinequan


Manufacturer: Roerig Div Pfizer Inc

Sinequan is a medication approved for the treatment of psychological disorders like depression. It is composed of Doxepin Hydrochloride as the main active component, which is a tricyclic antidepressant. It is available in different dosages 10 mg, 25 mg, and 75 mg that is composed as a conventional tablet form.

SKU: Roerig Sinequan Categories: ,

Available Options

Generic Sinequan - 10mg

Pack SizePrice/unitPriceQtyAdd to cart
90 pills$0.23$20.70
120 pills$0.22$26.77
180 pills$0.21$38.50
240 pills$0.20$49.13
300 pills$0.19$57.96

Generic Sinequan - 25mg

Pack SizePrice/unitPriceQtyAdd to cart
90 pills$0.27$24.30
120 pills$0.26$31.43
180 pills$0.25$45.20
240 pills$0.24$57.67
300 pills$0.23$68.04

Generic Sinequan - 75mg

Pack SizePrice/unitPriceQtyAdd to cart
60 pills$0.38$22.80
90 pills$0.37$33.17
120 pills$0.35$42.41
180 pills$0.35$62.24
240 pills$0.34$81.17
300 pills$0.32$96.90


Active Ingredient

The active component in the given medicine is Doxepin Hydrochloride, which is a dibenzoxepin derivative. It acts as a tricyclic antidepressant with antipruritic and sedative activities. This ingredient works by blocking the reuptake of norepinephrine and serotonin into presynaptic terminals to prolong the availability of the monoaminergic neurotransmitters. It enhances the action that leads to sedative effects. It also has antagonistic effects on histamine and muscarinic receptors. The antipruritic effect of this factor is the consequence of inhibition of histamine receptors.


Given an anti-depressant, Sinequan is indicated for the treatment of psychoneurotic people with depression and/or anxiety caused by alcoholism. Depression or anxiety is associated with organic disease i.e. the possibility of drug interaction should be considered if the person is receiving other drugs concomitantly. It also treats Psychotic depressive disorders like involutional depression and manic-depressive disorders.

This medication treats symptoms like tension, depression, somatic symptoms, and concerns, sleep disturbances, guilt, lack of energy, fear, apprehension, and worry.

Action Mechanism

The exact mechanism of the medicine is not known. It is stated by scientists that, it may block the brain from reabsorbing norepinephrine, a chemical messenger that affects the mood. This action of Sinequan maximizes the levels of norepinephrine in the body, which helps improve mood.


This particular medicine is available in dosages as given below:

  • 10 mg: It should be taken 1 to 3 times daily or as directed by the doctor
  • 25 mg: It is to be administered 1 to 3 times a day as prescribed by the doctor, or can take a tablet at bedtime to avoid dizziness
  • 75 mg: Medicine works best when consumed as prescribed in moderation and as recommended by the doctor


This medicine can cause serious fast/irregular heartbeat and other symptoms such as severe dizziness, and fainting that need medical attention right away.


What is Sinequan?

Sinequan belongs to a group of medicines called tricyclic antidepressant that affects chemicals in the brain that may be unbalanced.

What is Sinequan used for?

Doxepin is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

When should avoid taking Sinequan?

Avoid taking Sinequan, when used as an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

How should Sinequan be taken?

Follow all directions on the prescription label. The doctor may occasionally change the prescribed dose to make sure to get the best results. Do not take doxepin in larger or smaller amounts or for longer than recommended.

What should be avoided while taking Sinequan?

Do not drink alcohol. Sinequan can increase the effects of alcohol, which could be dangerous. Sinequan may impair thinking or reactions. Be careful if driving or doing anything that requires you to be alert.

Additional information


10mg, 25mg, 75mg


90 pills, 120 pills, 180 pills, 240 pills, 300 pills


$0.23, $0.22, $0.21, $0.20, $0.19


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