Sinequan is a medication approved for the treatment of psychological disorders like depression. It is composed of Doxepin Hydrochloride as the main active component, which is a tricyclic antidepressant. This medicine is manufactured by a trusted pharmaceutical company, Roerig pharmaceuticals. It is available in different dosages 10 mg, 25 mg and 75 mg that is composed as a conventional tablet form.
Active Ingredient: Active component in the given medicine is Doxepin Hydrochloride, which is a dibenzoxepin derivative. It acts as a tricyclic antidepressant with antipruritic and sedative activities. This ingredient works by blocking the reuptake of norepinephrine and serotonin into presynaptic terminals so as to prolong the availability of the monoaminergic neurotransmitters. It enhances the action that leads to sedative effects. It also has antagonistic effects on histamine and muscarinic receptors. The antipruritic effect of this factor is the consequence of inhibition of histamine receptors.
Indications: Given anti-depressant, Sinequan is indicated for the treatment of psychoneurotic people with depression and/or anxiety caused by alcoholism. Depression or anxiety is associated with organic disease i.e. the possibility of drug interaction should be considered if the person is receiving other drugs concomitantly. It also treats Psychotic depressive disorders like involutional depression and manic-depressive disorders.
This medication treats symptoms like tension, depression, somatic symptoms, and concerns, sleep disturbances, guilt, lack of energy, fear, apprehension, and worry.
Action Mechanism: The exact mechanism of the medicine is not known. It is stated by scientists that, it may block the brain from reabsorbing norepinephrine, a chemical messenger that affects the mood. This action of Sinequan maximizes the levels of norepinephrine in the body, which helps improve the mood.
Dosages: This particular medicine is available in dosages as given below:
- 10 mg: It should be taken 1 to 3 times daily or as directed by the doctor
- 25 mg: It is to be administered 1 to 3 times a day as prescribed by the doctor, or can take this tablet at bedtime to avoid dizziness
- 75 mg: Medicine works best when consumed as prescribed in moderation and as recommended by the doctor
Note: This medicine can cause serious fast/irregular heartbeat and other symptoms such as severe dizziness, fainting that need medical attention right away.