Prograf is composed as a capsule that helps to accept the new organ in people who have had a kidney, liver, or heart transplant. Tacrolimus is used as active ingredient in this medicine. The active ingredient is a drug from class immunosuppressants. Astellas Pharma US, Inc., the trusted pharmaceutical company has been manufacturing this effective medicine. It is available in dosage of 0.5 mg and 5 mg
Manufacturer: Astellas Pharma US, Inc.
Active Ingredient: The given medicine contains Tacrolimus as active ingredient. It is a calcineurin inhibitor immunosuppressant agent mostly known as means of prophylaxis against cellular rejection after transplantation. This ingredient exhibits immunosuppressive properties in vivo and prevents the T-lymphocytes activation in response to stimulation of antigenic or mitogenic.
Indications: The given medicine is indicated for the prophylaxis of organ rejection, in people receiving allogeneic kidney transplant, liver transplants and heart transplant in combination with other immunosuppressant medicine. This medicine can be used with other medicines also. It prevents the prevents attack of the immune system on the new organ i.e. transplanted organ.
Action Mechanism: This given drug Prograf decreases the effectiveness of the body's defense system i.e. immune system that helps the body to accept the new organ as if it were their own. The active ingredient in the medicine works by binding the immunophilin FK Binding Protein-12 to generate an immunosuppressive complex. It binds to a key regulatory kinase. This process stimulates the immune system and inhibit production of antibody.
Dosages: The medicine Prograf is composed as capsule. This capsule is available as following:
• 0.5 mg: Take this drug every 12 hours with or without food. Take the medicine with food to avoid nausea or stomach upset
• 5 mg: This tablet must be taken every 12 hours exactly as directed by the doctor
Note: The given medicine should not be used without supervision of the doctor with experience in immunosuppressive therapy. This capsule should not be crushed or opened before consumption. Consumption of grapefruit is contraindicated with this medicine.