Diamox is an effective solution to prevent or reduce high altitude sickness. This effective pill is manufactured by the renowned pharmaceutical company, Pfizer Limited. The main active ingredient in the medicine is Acetazolamide. It is made available in a dosage of 250 mg.
Manufacturer: Pfizer Limited
Active Ingredient: This medication is composed of the main active ingredient Acetazolamide. This main component belongs to a group of medicines known as carbonic anhydrase inhibitors. It is a reversible inhibitor of the carbonic anhydrase enzyme. That leads to a reduction of hydrogen ion secretion at the renal tubule and increased renal excretion of sodium, potassium, bicarbonate, and water.
This medication can be used as a diuretic or for the treatment of glaucoma. It works to prevent excessive build-up of aqueous humor. It inhibits carbonic anhydrase in the central nervous system to minimize abnormal and excessive discharge from CNS neurons. It is recommended in people with a metabolic alkalosis to promote retention of hydrogen ions at the level of the renal tubule.
Indications: Mentioned medication is approved to prevent and reduce the symptoms of altitude sickness. It can reduce headache, tiredness, nausea, dizziness, and shortness of breath that can occur at high altitudes generally above 10,000 feet/3,048 meters. It is specifically useful in situations when an individual cannot make a slow ascent.
It is also indicated for the treatment of high pressure inside the eye due to certain types of glaucoma. It reduces the production of fluid inside the eye and decreases a buildup of body fluids caused by heart failure or certain medications.
Action Mechanism: The active component Acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, for the reduction of Intraocular pressure. This leads to a reduction in aqueous humor formation and thus lowering of IOP occurred.
Diamox shows systemic effects that include increased renal loss of sodium, potassium, and water secondary to the drug’s renal tubular effects. Due to this arterial blood gases might show a mild hyperchloremic metabolic acidosis.
Dosages: The medicine is recommended to reduce altitude sickness. Diamox dosage is as follows:
- 250 mg: This tablet must be taken 1 to 4 times a day exactly as prescribed by the doctor
Note: This medicine can be taken with or without food. It is advisable to drink plenty of fluids unless otherwise directed by the doctor. The dosage is based on the medical condition and response to treatment.