Description
Active Ingredient
The main active component of this medicine is Chloroquine, which is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization as well as radiosensitization activities. It is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin to result in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids.
Indications
Chloroquine-composed of Aralen medication is used for treating acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum, Extraintestinal amebiasis. It is not effective for malaria prevention. It suppresses malaria infection, stops acute attacks, and lengthens the time between treatment and relapse.
Action Mechanism
This malaria treatment medicine is an anti-malarial drug. It is similar to hydroxychloroquine and is useful in treating several forms of malaria as well as amebiasis that has spread outside of the intestines. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and it may prevent malarial parasites from breaking down (metabolizing) hemoglobin in human red blood cells. Aralen is effective against the malarial parasites Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum.
Side Effects
Common Side Effects
- Accommodation Disorder
- Abdominal Pain With Cramps
- Abnormal Ecg
- Abnormal Hepatic Function Tests
- Acute Confusion
- Agitation
- Agranulocytosis
- Alopecia
- Anaphylaxis
- Angioedema
- Anorexia
- Aplastic Anemia
- Atrioventricular Block
- Blurred Vision
- Bundle Branch Block
- Cardiomyopathy
- Corneal Opacity
- Delirium
- Depression
- Diarrhea
- Dress Syndrome
- Drug-Exacerbated Psoriasis
- Drug-Induced Psychosis
- Dyschromia
- Eosinophilia
- Erythema Multiforme
- Exfoliative Dermatitis
- Extrapyramidal Disease
- Gastrointestinal Irritation
- Hair Bleaching
- Hallucinations
- Headache Disorder
- Hepatitis
- Hypoglycemic Disorder
- Hyporeflexia
- Hypotension
- Insomnia
- Maculopathy
- Mood Changes
- Mouth Discoloration
- Muscle Weakness
- Myopathy
- Nail Discoloration
- Nausea
- Neutropenic Disorder
- Night Blindness
- Ototoxicity
- Pancytopenia
- Peripheral Motor Neuropathy
- Peripheral Sensory Neuropathy
- Personality Disorders
- Polyneuropathy
- Prolonged Qt Interval
- Pruritus Of Skin
- Retinal Disorder
- Scotomata
- Seizure Disorder
- Skin Photosensitivity
- Skin Rash
- Stevens-Johnson Syndrome
- Stomatitis
- Suicidal
- Symptoms Of Anxiety
- Thrombocytopenic Disorder
- Torsades De Pointes
- Toxic Epidermal Necrolysis
- Urticaria
- Ventricular Fibrillation
- Ventricular Tachycardia
- Visual Field Defect
- Vomiting
If You face any of these effects persist or worsen, tell your doctor or pharmacist immediately:
- Blurred vision
- Headache
- Nausea
- Vomiting
- Abdominal cramps
- Diarrhea
Serious Side Effects
- Bleaching of hair color
- Darkening of skin/tissue inside the mouth
- Easy bruising/bleeding
- Hair loss
- Hearing changes
- Mental/mood changes
- Muscle weakness
- Pale lips/nails/skin
- Shortness of breath
- Signs of liver disease
- Signs of serious infection
- Swelling legs/ankles
- Unusual tiredness
- Unwanted/uncontrolled movements
- Worsening of skin conditions
Very Serious Side Effects
- Severe dizziness
- Fainting
- Fast/slow/irregular heartbeat
- Seizures
Symptoms Of Serious Eye Problems, including:
- Severe vision changes
Serious Allergic Reaction
- Rash
- Itching/swelling
- Severe dizziness
- Trouble breathing.
Interactions
Before taking this drug, tell your doctor if you’ve had:
- A certain enzyme problem (glucose-6-phosphate dehydrogenase deficiency-G6PD)
- Vision/eye problems
- Hearing problems
- Kidney disease
- Liver disease
- Regular alcohol use/abuse
- Psoriasis
- A certain blood disorder (porphyria)
- Seizures
Products Interactions
- Agalsidase
- Mefloquine
- Penicillamine
- Sulfadoxine/pyrimethamine
- Products that may harm the liver (such as acetaminophen, isoniazid, and alcohol)
Dosages
This anti-malarial medicine is available for oral consumption and in dosage as mentioned below:
- 250 mg: This medication must be taken with food to prevent stomach upset, exactly as directed by the doctor
- 500 mg: This drug is advisable to take with food as directed by the doctor.
Alternatives For Generic Aralen
Note
Stopping the prevention or treatment of this drug too soon may lead to infection or a return of the infection.
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