Active Ingredient: The main active component of this medicine is Chloroquine, which is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization as well as radiosensitization activities. It is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin so as to result in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids.
Indications: Chloroquine composed Aralen medication is used for treating acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum, Extraintestinal amebiasis. It is not effective for malaria prevention. It suppresses malaria infection, stops acute attacks, and lengthens the time between treatment and relapse.
Action Mechanism: This malaria treating medicine an anti-malarial drug. It is similar to hydroxychloroquine and is useful in treating several forms of malaria as well as amebiasis that has spread outside of the intestines. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and it may prevent malarial parasites from breaking down (metabolizing) hemoglobin in human red blood cells. Aralen is effective against the malarial parasites Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum.
Dosages: This anti-malarial medicine is available for oral consumption and in dosage as mentioned below:
- 250 mg: This medication must be taken with food to prevent stomach upset, exactly as directed by the doctor
- 500 mg: This drug is advisable to take with food as directed by the doctor
Note: Stopping the prevention or treatment of this drug too soon may lead to infection or a return of the infection.