Zofran ODT contains Ondansetron as the main active ingredient that acts as a serotonin 5-HT3 receptor antagonist. This medicine is intended to use to prevent and treat nausea and vomiting induced due to chemotherapy or radiation therapy. It is available as orally disintegrating tablets in dosage as 4 mg and 8 mg. Novartis Pharmaceuticals Corporation, one of the growing pharmaceutical company manufactures this drug.
Manufacturer: Novartis Pharmaceuticals Corporation
Active Ingredient: Ondansetron is a serotonin 5-HT3 receptor antagonist intended to treat nausea and vomiting following chemotherapy. The medication’s effects are thought to be on both peripheral and central nerves. It reduces the activity of the vagus nerve that a nerve, which activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. This drug does not have much effect on vomiting due to motion sickness. It does not have any effect on dopamine receptors or muscarinic receptors.
Indications: Mentioned medicine is indicated with other drugs to prevent nausea and vomiting induced by cancer drug treatment and radiation therapy. This medicine is also approved for the prevention and treatment of nausea and vomiting after surgery. Zofran ODT blocks one of the natural substances in the body that causes vomiting.
Action Mechanism: Ondansetron composed medicine is an anti-nausea drug most often used to prevent nausea and vomiting induced by chemotherapy. These agents increase the secretion of serotonin that stimulates serotonin receptors in the brain, causing nausea and vomiting. Zofran ODT works by selectively blocking serotonin receptors, decreasing the effect of increased serotonin due to chemotherapy.
Dosages: This medication is available as orally disintegrating tablets for oral consumption as mentioned below:
- 4 mg: This tablet may be taken up to 3 times a day for 1 to 2 days after the chemotherapy or radiation treatment is finished, as directed by the doctor
- 8 mg: It must be taken 3 times a day after the therapy as prescribed by the doctor
Note: The medical history of irregular heartbeat, liver disease, stomach/intestinal problems, recent abdominal surgery, ileus, swelling should be discussed with the doctor.