Active Ingredient: The main active component of this medicine is Voriconazole. This is a synthetic triazole with antifungal activity. This active factor inhibits 14-alpha-lanosterol demethylation in fungi, that prevents the production of ergosterol, an essential constituent of the fungal cell membrane, and resulting in fungal cell lysis. It is a triazole-based antifungal agent indicated to treat esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. This plays the role of a P450 inhibitor. It belongs to a pyrimidine, tertiary alcohol, a triazole antifungal drug and a conazole antifungal drug.
Indications: Voriconazole composed medicine is used in adults and children 2 years of age and older for the treatment of serious fungal infections like invasive aspergillosis, a fungal infection that begins in the lungs and spreads through the bloodstream to other organs, esophageal candidiasis, a yeast infection that may cause white patching in the mouth and throat, and candidemia, a fungal infection in the blood. Vfend also treats certain other fungal infections when other drugs will not work for certain people. It is in a class of antifungal medications called triazoles that slows the growth of the fungi that cause infection.
Action Mechanism: Given medicine is a triazole antifungal agent that acts by inhibition of fungal cytochrome P-450 and sterol C-14 alpha-demethylation. Vfend decreases ergosterol synthesis and inhibits fungal cell membrane formation.
Dosages: This antifungal medicine is available in dosages as mentioned below:
- 50 mg: This medication should be taken at least 1 hour before or 1 hour after meals every 12 hours without food as directed by the doctor
- 200 mg: It is to be consumed 1 hour before or 1 hour after a meal as advised by the doctor
Note: This medicine is not recommended in breastfeeding women, it may harm nursing infants.
What is Vfend?
Vfend is an antifungal medicine. Vfend is used to treat infections caused by yeast or other types of fungus.
What is the most important information should be known about Vfend?
Tell the doctor about all current medicines treating with. Many drugs can interact, and some drugs should not be used together.
How should Vfend be taken?
Follow all directions on the prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take oral Vfend (tablets or liquid) at least 1 hour before or 1 hour after eating a meal.
What other drugs will affect Vfend?
Many drugs can affect voriconazole, and some drugs should not be used at the same time. tell the doctor about prescription and over-the-counter medicines, vitamins, and herbal products in case consuming.
What are the possible side effects of Vfend?
Get emergency medical help in case of having signs of an allergic reaction (hives, difficult breathing, swelling in the face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).