Active Ingredient: Telmisartan / Amlodipine Besylate, is a combination of two active ingredients present in the given medication. Telmisartan is a non-peptide angiotensin II receptor antagonist that has antihypertensive properties. It antagonizes angiotensin II binding to the AT1 subtype receptor.
Amlodipine Besylate is a synthetic dihydropyridine that has antihypertensive and antianginal effects. This drug inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells to prevent the vascular and myocardial contraction. As a consequence, the dilatation of the main coronary and systemic arteries, reduced myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue and decreased total peripheral resistance.
Indications: This combination of two components is indicated to treat high blood pressure i.e. hypertension. Decreasing high blood pressure helps prevent strokes, heart attacks, and kidney problems. Twynsta contains telmisartan and amlodipine. Telmisartan is an angiotensin receptor blocker and amlodipine is a calcium channel blocker that relaxes the blood vessels so that blood can flow more easily.
Action Mechanism: This mentioned medication Twynsta is a combination of angiotensin receptor blocker and calcium channel blocker. Telmisartan works by blocking the effect of angiotensin that makes blood vessels relax more and allows the kidney to get rid of excess water and salt. It also helps lower blood pressure. Amlodipine blocks calcium from entering certain tissues and arteries. This makes it easier for them to relax so that blood can flow more easily to the heart. It reduces the risk of heart attack or stroke.
Dosages: This medicine is made available in dosages as given below:
- 5mg/40mg: It is to be taken once a day with or without food as directed by the doctor
- 5mg/80mg: This drug is advised to be consumed before or after a meal as prescribed by the doctor
Note: This medicine is not recommended in women who are pregnant or breastfeeding a baby; it may harm an unborn baby or nursing infant.