Description
Active Ingredient
The main active component of the medication is Pioglitazone, which is an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. It activates peroxisome proliferator-activated receptor gamma, a ligand-activated transcription factor, so as to cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.
Indications
Pioglitazone composed medication Actos is a diabetes drug called “glitazones” used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body’s proper response to insulin, thereby lowering your blood sugar.
Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It is used either alone or in combination with other diabetes medications.
Action Mechanism
Given medicine is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. Actos decrease insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output.
Dosages
This effective medicine is available for oral consumption and in dosage as mentioned below:
- 15 mg: It shall be taken with or without food as directed by your doctor, usually once a day
- 30 mg: It is to be consumed with or without food exactly as mentioned in the prescription by the doctor
- 45 mg: This tablet shall be taken once a day with or without as advised by the doctor.
Common Side Effects
- Dizziness
- Pharyngitis
- Upper Respiratory Infection
- Sinusitis
- Flatulence
- Myalgia
- Urinary Tract Infection
- Headache Disorder
- Body Fluid Retention
- Edema
- Weight Gain
- Hepatitis
- Abnormal Hepatic Function Tests
- Fracture
- Ovulation Stimulation
- Malignant Tumor Of Urinary Bladder
- Hepatic Failure
- Macular Retinal Edema
- Worsening Of Chronic Heart Failure
- Heart Failure
Tell your doctor right away if you have any serious side effects, including
- New/worsening vision problems
- Bone fracture
- Urgent need to urinate
- Pain while urinating
- Reddish-colored urine
Pioglitazone may rarely cause liver disease. Symptoms of liver disease, including:
- Dark urine
- Yellowing of eyes/skin
- Persistent nausea/vomiting
- Stomach/abdominal pain
Symptoms Of A Serious Allergic Reaction
- Rash
- Trouble breathing
- Itching/swelling
Note
Stop using this medicine if you have shortness of breath, swelling, or rapid weight gain.
Other Popular Medications To Treat Diabetes
- Generic Precose
- Generic Diamicron mr
- Generic Diamicron
- Generic Amaryl
- Generic Glucotrol Xl
- Generic Glucotrol
- Generic Glucophage
- Generic Glucophage Xr Extended Release
- Generic Starlix
- Generic Actos
- Generic Prandin
- Generic Avandia
- Generic Januvia
FAQ’s
When did Actos first come on the market?
Actos was introduced in 1999 as a drug to treat type 2 diabetes.
What are the side effects of Actos?
There are many side effects by Actos. The most serious is bladder cancer.
When a drug is approved by the FDA – like Actos – isn’t the drug safe?
No. The FDA does not have the staff or facilities to test drugs. FDA warnings and FDA recalls are often based on the work of others.
Must I prove my cancer is directly linked to Actos before I can file a lawsuit?
Yes, if you are certain that your medical condition has been caused due to the use of Actos, then you should file it.
I’ve taken Actos for a while, am I at risk for developing bladder cancer?
Taking Actos for over two years face an increasing risk of developing bladder cancer.
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