Active Ingredient: It is composed of an active component Quinapril Hydrochlorid, which is the hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme inhibitor with antihypertensive activity. It hydrolyzed into its active form nonpuerility, which binds to and inhibits ACE, to block the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. It causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, to promote diuresis and natriuresis, and increases bradykinin levels.
Indications: This medication is used to treat high blood pressure. This lowers high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication Accupril is also used to treat heart failure. It belongs to a class of drugs known as ACE inhibitors that work by relaxing blood vessels so blood can flow more easily.
Action Mechanism: Quinapril composed medication is denitrified to the principal metabolite. Accupril is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 5 mg: It is to be taken with or without food as directed by the doctor, usually once or twice a day
- 10 mg: This medicine shall be consumed once or twice a day exactly a prescribed by the doctor
- 20 mg: Administer this medicine once or twice a day as directed by the doctor
Note: Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril.