Active Ingredient: The main active ingredient of this medicine is Balsalazide Disodium, which is the disodium salt form of this ingredient, an aminosalicylate. It is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. It acts on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites, including leukotrienes, prostaglandins and hydroxyeicosatetraenoic acids, and other inflammatory agents. It is used to treat chronic inflammatory bowel disease.
Indications: Balsalazide Disodium composed medicine Colazal is used to treat a certain bowel disease or ulcerative colitis. It helps to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain. It belongs to a class of drugs known as aminosalicylates. It decreases swelling in the colon.
Action Mechanism: It believed to be by reducing inflammation in the colon. Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals; Prostaglandins are produced by the enzymes, cyclooxygenase and lipoxygenase. These enzymes are over-active in individuals with ulcerative colitis. Colazal may work by blocking the activity of cyclooxygenase and lipoxygenase, to reduce the production of prostaglandins. Reduced production of prostaglandins decreases inflammation in the colon and the symptoms associated with ulcerative colitis.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 750 mg: it is to be consumed with or without food, usually 3 times daily or as directed by the doctor
Note: This medication contains sodium. Talk to the doctor before consuming this medicine if you are on a low salt diet.
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