Baraclude is a medicinal drug intended to treat liver disease. It mainly treats long-term hepatitis B infection. The main active ingredient of this medicine is Entecavir. It does not cure the infection, but it controls spreading. Bristol Myers Squibb, one of the renowned pharmaceutical companies manufactured this drug. It is made available in the form of conventional tablet form and available in dosages 0.5 mg and 1 mg.
Manufacturer: Bristol Myers Squibb
Active Ingredient: The active ingredient of the medication is Entecavir, which is an anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). This component is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate for incorporation into viral DNA. It also inhibits the reverse transcriptase viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.
Indications: Entecavir composed medicine Baraclude is used to treat long-term hepatitis B infection. This is an infection of the liver caused by the hepatitis B virus. Long-term infection can cause liver damage, rarely liver cancer, and liver failure. This medicine helps to decrease the amount of hepatitis B virus in your body. It lowers your chance of getting liver cancer or liver damage. This drug is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.
Action Mechanism: This mentioned medicine is a nucleoside analog, or more specifically, a deoxyguanosine analogue. Baraclude belongs to a class of carbocyclic nucleosides and inhibits reverse transcription, DNA replication and transcription in the viral replication process.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 0.5 mg: Take this medication on an empty stomach at least 2 hours after a meal and 2 hours before the next meal, as directed by the doctor, usually once a day
- 1 mg: It is advisable to take this medicine once a day on an empty stomach, as prescribed by the doctor
Note: Before using this drug, consult the doctor about the medical history, especially of: HIV infection, kidney disease, or hepatitis B drugs taken in the past.