Active Ingredient: The main active component of this medicine is Methyldopa, which is a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. This component is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This leads to a decrease in sympathetic outflow and decreased blood pressure.
Indications: This medication is used alone or with other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Aldomet relaxes blood vessels so blood can flow more easily.
Action Mechanism: Methyldopa composed Aldomet medication is thought to lower blood pressure by activating receptors (alpha-2 receptors) in the central nervous system and by reducing the concentration of epinephrine, norepinephrine, dopamine, and serotonin.
Epinephrine, norepinephrine, dopamine, and serotonin are neurotransmitters (chemicals) that nerves use to communicate. Reducing the concentration of these neurotransmitters causes blood vessels to dilate (relax or widen), and, as a result, blood pressure is reduced.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 250 mg: Take this medication with or without food as directed by the doctor, usually 2 to 4 times a day
Note: You should not take this medicine if you have liver disease especially cirrhosis or a history of liver problems caused by taking this medicine.
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