Active Ingredient: Vardenafil is a PDE-5 inhibitor that works well over impotence in men. The medicine was initially manufactured and marketed solely by the patent holders, Bayer and GlaxoSmithKline, until the final expiry of the patent occurred in October 2018. Nowadays there are several pharma companies composing generic vardenafil-medications. The brands most commonly found online are Valif by Ajanta Pharma.
Indication: All versions of Vardenafil composed medicines are intended for the treatment of impotence and it might have the same therapeutic effect and side effects, indications, contraindications, and directions for use. The differences might include the name of the manufacturer, the brand, dosage form, appearance, strength, and price. Some vardenafil-based medicine might also contain Dapoxetine, which is an additional active ingredient that is used for the treatment of premature ejaculation in impotent men.
Action Mechanism: When a man might be sexually aroused, the nerve endings in the penile shall release nitric oxide (NO). This NO might trigger the production of cyclic guanosine monophosphate (cGMP). Further, the enzyme cGMP makes blood vessels inside the penile body to widen so that the appropriate amount of blood and move in. Penile shall further be filled up with blood and remains engorged for the duration of sexual lovemaking session.
Dosages: The medicine Valif composed of Vardenafil is available in one dosage as mentioned:
- 20 mg: Pill is to be consumed within an hour of planned sex and in most cases, it helps to attain an erection in simply 30 minutes that shall last for approx. 4 hours, provided you are sexually aroused
Note: When the lovemaking session is over, another substance known as phosphodiesterase type-5 (PDE-5) degrades cGMP, the blood vessels shall become narrower again and the penile might return to its flaccid state.