Active Ingredient: This medication is a combination of two active ingredients Valsartan / Hydrochlorothiazide. Valsartan an active nonpeptide triazole-derived antagonist of angiotensin II with antihypertensive properties. This component blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium. It leads to vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.
Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. Its metabolite appears to bind to and accumulate in red blood cells. It is excreted by the kidneys. It is a diuretic used for the treatment of hypertension and congestive heart failure. It plays the role of a xenobiotic, an environmental contaminant, a diuretic, and an antihypertensive agent.
Indications: It is a combination of two active ingredients. It has a thiazide diuretic that helps prevent the body from absorbing too much salt, which can cause fluid retention. Another component is an angiotensin II receptor antagonist that keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Diovan HCT is a combination medicine used to treat high blood pressure that lowers the blood pressure, which may lower the risk of a stroke or heart attack.
Action Mechanism: Given medication blocks the action of angiotensin II, a chemical in the body that causes blood vessels to tighten and narrow. Diovan HCT helps to relax and widen the blood vessels, which lowers blood pressure. It may work by removing sodium and water from the body.
Dosages: This high blood pressure treating medicine is available in dosages as given below:
- 80mg/12.5mg: It must be taken once a day with or without food as directed by the doctor
- 160mg/12.5mg: This drug is to be consumed once a day as directed by the doctor
- 160mg/25mg: This tablet shall be taken once a day as mentioned in the prescription by the doctor
Note: This medication is not recommended in people who have kidney disease.