Active Ingredient: The active component of this medication is Captopril, which is a sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. It inhibits angiotensin-converting enzyme, so as to decrease levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. It also inhibits tumor angiogenesis by inhibiting endothelial cell-matrix metalloproteinases and endothelial cell migration. It may also exhibit antineoplastic activity independent of effects on tumor angiogenesis.
Indications: Captopril composed medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Capoten is also used to treat heart failure, protect the kidneys from harm due to diabetes, and to improve survival after a heart attack. It is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily.
Action Mechanism: Given medication is an angiotensin-converting enzyme (ACE) inhibitor dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart
Capoten promotes sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 12.5 mg: This tablet shall be taken on an empty stomach at least 1 hour before meals as directed by the doctor, usually two to three times a day
- 25 mg: Take this medication exactly as directed by the doctor, usually 2 to 3 times a day
Note: While treating with this medicine, to reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
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