Aldactazide is an effective medicine used in the treatment of high blood pressure. It has a combination of two active ingredients, Spironolactone / Hydrochlorothiazide. It is a combination of an aldosterone receptor antagonist and diuretic. It is manufactured by the leading pharmaceutical company, G.D. Searle LLC (Pfizer Inc). This medication is offered in a dosage of Spironolactone 25 mg + Hydrochlorothiazide 25 mg.
Manufacturer: G.D. Searle LLC (Pfizer Inc)
Active Ingredient: This medicine is a combination of two ingredients i.e. Spironolactone and Hydrochlorothiazide. Spironolactone is a corticosteroid that has potassium-sparing diuretic, antihypertensive, and antiandrogen activities. This active component inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. It also inhibits the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.
Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It appears to preferentially bind to and accumulate in red blood cells and excreted by the kidneys. Hydrochlorothiazide is a diuretic used for the treatment of hypertension and congestive heart failure. It plays the role of a xenobiotic, an environmental contaminant, a diuretic, and an antihypertensive agent. It is a benzothiadiazine, a sulfonamide and an organochlorine compound.
Indications: This mentioned medicine is indicated to treat high blood pressure, heart failure, or extra fluid in the body. Aldactazide lowers the high blood pressure that helps prevent strokes, heart attacks, and kidney problems.
It has diuretics that cause the body to get rid of extra salt and water. It also helps to relax the blood vessels so that blood can flow more easily and may increase the amount of urine produced. It helps to treat or prevent low blood potassium levels and block the activity of a certain natural substance that can cause edema.
Action Mechanism: This drug is a combination of Spironolactone and hydrochlorothiazide called diuretics. Spironolactone is called a potassium-sparing diuretic that helps the body to retain potassium. Hydrochlorothiazide causes potassium to be lost from the system. Potassium supplements are usually not required with Aldactazide as the effects of the two diuretics balance each other out.
Dosages: This drug is made available in a dosage as mentioned below:
- 25mg/25mg: It is to be consumed once or twice a day with or without food exactly as directed by the doctor
Note: This medicine should not be used in pregnant or breastfeeding women; it may harm the development of a fetus.