Isordil is offered by one of the growing pharmaceutical companies, Wyeth Ltd. It is composed of the main active ingredient Isosorbide dinitrate, which belongs to a class of drugs known as nitrates. It is approved for the prevention of chest pain in people with a certain heart condition. It is available in dosages of 5 mg and 10 mg for oral consumption as a conventional tablet form.
Manufacturer: Wyeth Ltd.
Active Ingredient: This particular medication is composed of Isosorbide Dinitrate as the main active component. This active component is the dinitrate salt form of isosorbide that shows vasodilator activity. It acts by relaxing the vascular smooth muscle by the formation of the free radical nitric oxide that is identical to the endothelium-derived relaxing factor. This nitric oxide activates guanylyl cyclase so as to increase the synthesis of cGMP within a smooth muscle. It leads to dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. It also relaxes coronary arteries to increase blood circulation through the ischemic area.
Indications: Given effective medication is indicated to prevent chest pain in people with a certain heart condition like coronary artery disease. Isordil belongs to a class of drugs called nitrates that relaxes and widens blood vessels so blood can flow more easily to the heart.
It will not relieve chest pain once it occurs. It is also not prescribed to be consumed just before physical activities like exercise, sexual activity to prevent chest pain.
Action Mechanism: This type of drug is a vasodilator. This medication works by improving the flow of blood and oxygen to the heart and decrease the work that the heart must do by expanding the arteries and veins in the body. Due to the widening of these arteries, it reduces the amount of blood that returns to the heart that must be pumped. Isordil lowers the pressure in the arteries against which the heart must pump. The heart works less and requires less blood and oxygen. It also dilates the arteries that supply the heart with blood so that the heart receives more blood and oxygen.
Dosages: It is available in the following dosages:
- 5 mg: It should be taken 2 to 3 times a day or as directed by the doctor, do not go against it
- 10 mg: This medicine is to be consumed 2 to 3 times a day as prescribed by the doctor
It should not be used in case of having a certain medical condition like a head injury or head surgery.