Active Ingredient: Rifaximin is a non-systemic antibiotic derived from rifamycin SV with antibacterial activity. This antibiotic binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth. This drug is not well absorbed, its antibacterial activity is largely localized to the gastrointestinal tract. This medication is a nonabsorbable antibiotic that is indicated as treatment and prevention of travelers’ diarrhea. It is used for the prevention of hepatic encephalopathy in people with advanced liver disease and to treat diarrhea in people with irritable bowel syndrome.
Indications: This mentioned medication is approved for the treatment of diarrhea induced by the common bacteria known as E. coli also called traveler’s diarrhea. Xifaxan is not recommended to treat fever or bloody diarrhea. It is an antibiotic that only treats bacterial infections. It is not effective for the treatment of common cold, flu.
It is also indicated to treat irritable bowel syndrome with diarrhea. It prevents a brain problem caused by the liver disease that helps to think more clearly.
Action Mechanism: This medicine is active against Escherichia coli bacterial strains that induce traveler’s diarrhea. Xifaxan acts by preventing the growth of the bacteria by preventing them from manufacturing proteins responsible for their replication and survival. This suppressing growth of the bacteria, this drug reduces symptoms of traveler’s diarrhea. Hepatic encephalopathy is a serious neurologic complication of liver disease that affects the brain. It prevents and treats hepatic encephalopathy by decreasing the intestinal bacteria that produce ammonia.
Dosages: Given antibiotic medicine is available in dosage as mentioned below:
- 200 mg: It should be taken 3 times a day for 3 days with or without food as directed by the doctor
- 550 mg: It is to be consumed 3 times a day for 3 days as advised by the doctor
Note: Medical history of severe liver disease, diarrhea with fever, or diarrhea that is watery or has blood in it before taking this medication.