Coumadin is an effective medication used in the treatment of blood clots or pulmonary embolus. This medication is an anticoagulant composed of active component Warfarin. This popular branded medication is been manufactured by the leading pharmaceutical company, Bristol-Myers Squibb. It is offered in a conventional tablet from in various dosages 1 mg, 2 mg, 3 mg, and 5 mg.
Manufacturer: Bristol-Myers Squibb
Active Ingredient: The main active component of this medicine is Warfarin. This active ingredient is a synthetic anticoagulant. It inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, and the anticoagulant proteins C and S. It leads to the sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. It also promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.
Indications: This given medication is used to treat blood clots like in deep vein thrombosis-DVT or pulmonary embolus-PE and to prevent new clots from forming in your body. Coumadin prevents harmful blood clots helps to reduce the risk of a stroke or heart attack. Conditions that increase your risk of developing blood clots include a certain type of irregular heart rhythm, heart valve replacement, recent heart attack, and certain surgeries.
This medicine is commonly called a blood thinner that helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances in the blood.
Action Mechanism: The formation of a clot in the body is a complex process that involves multiple substances called clotting factors. Warfarin composed Coumadin medicine decreases the body's ability to form blood clots by blocking the formation of vitamin K–dependent clotting factors.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 1 mg: This is an oral drug shall be taken with or without food as directed by the doctor, usually once a day
- 2 mg: It is to be taken once a day before or after a meal as advised by the doctor
- 3 mg: This medicine is advisable to consume as directed by the doctor, do not take extra dosage
- 5 mg: This conventional tablet must be taken orally with a glass of water as directed by the doctor
Note: It is important to eat a balanced, consistent diet while treating with this medicine.