Temodar is composed of an active ingredient Temozolomide, which is a cytotoxic alkylating agent. It is indicated in the treatment of cancer. Merck Sharp & Dohme Corp., a renowned pharmaceutical company manufactures this medicine. It is offered in the form of capsule form in dosages like 20 mg, 100 mg, and 250 mg.
Manufacturer: Merck Sharp & Dohme Corp.
Active Ingredient: Temozolomide is used as the main active component in the given medication. It shows an antineoplastic activity. It acts as a cytotoxic alkylating agent, which is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide. The cytotoxicity is due primarily to methylation of DNA at the O6 and N7 positions of guanine. It leads to the inhibition of DNA replication. This active component is metabolized to MITC at all sites and penetrates well into the central nervous system.
Indications: Temozolomide composed of medicine is indicated for the treatment of cancer. It interferes with the growth and spread of cancer cells in the body in the body. Temodar is approved with radiation therapy to treat certain types of brain tumors in adults and usually given after other cancer medicines have been tried without success.
Action Mechanism: This mentioned medication works by restricting cancer cells from forming DNA. DNA stands for DeoxyriboNucleic Acid, which is the genetic material of a cell. If the cancer cells stop making DNA, they can't split into new cells. This way Temodar restricts the cancer cells from growing.
Dosages: This cancer-treating medicine is available in dosages as mentioned below:
- 20 mg: It shall be taken once a day as directed by the doctor
- 100 mg: It is to be consumed once a day with or without food as advised by the doctor
- 250 mg: This medicine should be taken as mentioned in the prescription by the doctor
Note: This medication may increase the risk of developing certain types of bone marrow cancer. Discuss with the doctor about the individual risk.