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Dipyridamole-Acetylsalicylic Acid

[ Generic Medicines for Stroke Prevention Treatment ]

Dipyridamole / Acetylsalicylic Acid is a combination of two active ingredients. Dipyridamole is a derivative of pyrimido-pyrimidine that shows antiplatelet properties. This active component inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate and inhibiting the stimulation of platelet aggregation by agents like platelet-activating factor and collagen. It is only found in individuals that have taken this drug. This active ingredient is a phosphodiesterase inhibitor, which blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

Acetylsalicylic Acid is a non-steroidal anti-inflammatory agent that binds to and acetylates serine residues in cyclooxygenases, leads to a decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This active component exhibits analgesic, antipyretic, and anticoagulant properties.

Class of Drugs – Salicylates + Phosphodiesterase inhibitor

Molecular Formula – C24H40N8O4 + C9H8O4

Molecular Weight - 504.6 g/mol + 180.16 g/mol

Working: This combination of medication is a combination of salicylates and phosphodiesterase inhibitors. This Dipyridamole / Acetylsalicylic Acid works by decreasing substances in the body that cause pain, fever, and inflammation. It keeps platelets in the blood from sticking together to form clots.

Uses: This mentioned medication is approved to reduce the risk of stroke in people who have had mini-strokes or transient ischemic attacks or a previous stroke due to a blood clot. These are at high risk for another stroke. Dipyridamole / Acetylsalicylic Acid contains two medications, a very low dose of aspirin and dipyridamole in a slow-release form.

This is an antiplatelet drug that works to keep blood flowing to the brain by restricting platelets from clumping together. This also prevents the platelets from forming blood clots, which can lodge in the brain and cause a certain type of stroke.

Popular Brands and Dosages: The component is used in a popular brand to treat the mentioned condition as follows:

  • Aggrenox: 200 mg + 25 mg

seek medical attention if experienced continuous bleeding, black or bloody stools, or cough up blood or vomit that looks like coffee grounds.