Arava is an effective medication that affects the immune system and reduces swelling and inflammation in the body. It is used to treat the symptoms of rheumatoid arthritis. It has active ingredient Leflunomide, which is an anti-inflammatory agent. Mylan Pharma, one of the trusted pharmaceutical companies manufactures this medicine. It is made available in dosages like 10 mg and 20 mg.
Manufacturer: Mylan Pharma
Active Ingredient: The active component in the medicine is Leflunomide, which is a derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. It is converted to an active metabolite, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, so as to prevent the expansion of activated T lymphocytes. It inhibits various protein tyrosine kinases, such as protein kinase C to inhibit cell proliferation.
Indications: This medication is used to treat rheumatoid arthritis, a condition in which the body's defense system fails to recognize the body as itself and attacks the healthy tissues around the joints. This medicine helps to reduce the joint damage/pain/swelling and helps you to move better. Arava works by weakening your immune system and decreasing swelling.
Action Mechanism: Leflunomide composed medicine Arava reduces inflammation in the joints that is responsible for both the symptoms of rheumatoid arthritis and the destruction of joints. It reduces symptoms as well as the progressive deformities of the joints caused by the arthritis. It reduces inflammation by suppressing the activity of immune cells responsible for the inflammation.
It suppresses immune cells by inhibiting dihydroorotate dehydrogenase, an enzyme that is necessary for the production of DNA and RNA. Without DNA and RNA the immune cells cannot multiply or function.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 10 mg: It is to be taken with or without food, usually once a day or as directed by the doctor
- 20 mg: Take this medication once a day before or after a meal as advised by the doctor
Note: Use birth control to prevent pregnancy while you are taking this medication.