Phoslo is a popular brand of medication intended to treat renal failure. It is indicated for the control of hyperphosphatemia in end stage renal failure and does not promote aluminum absorption. Calcium Acetate is an active component of this medicine. Fresenius Pharmaceuticals, one of the renowned pharmaceutical companies manufactures this drug. It is made available in a conventional tablet form in a dosage of 667 mg.
Active Ingredient: The main active component of this medication is Calcium Acetate. It is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. It is also used to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.
This main component is the calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia i.e. excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form calcium phosphate, which is excreted in the stools. It has a role as a chelator.
Indications: Calcium acetate composed medication Phoslo is used to prevent high blood phosphate levels in patients who are on dialysis due to severe kidney disease. Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced.
Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels. Phoslo works by holding onto phosphate from the diet so that it can pass out of your body.
Action Mechanism: People with advanced kidney failure retain phosphate leading to too much phosphate in their bodies. High phosphate levels cause hyperparathyroidism, which leads to abnormal bone formation and calcium deposits in tissues. Phoslo is a phosphate binder, when taken with meals, combines with phosphate in food to form calcium phosphate, which is poorly absorbed into the body and is excreted in the feces. Binding phosphate in the intestines reduces absorption of phosphate into the body.
Dosages: This medication is available for oral consumption and in dosage as mentioned below:
- 667 mg: This medication is usually taken by mouth with each meal as directed by the doctor
Note: People with end stage renal failure may develop hypercalcemia when given calcium with meals.