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Tacrolimus

[ Generic Medicines for Men & Women Treatment ]

Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis. This is used as the main active component that binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, so as to inhibit the calcineurin phosphatase activity. It also resulting in reduced cytokine production. It exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. This component possesses similar immunosuppressive properties to cyclosporine, but is more potent.

Class of Drugs – Immunosuppressant

Molecular Formula – C44H69NO12

Molecular Weight - 804 g/mol

Working: Given medication is an immunosuppressant drug that works on the immune system and directly on skin cells. This action of the Tacrolimus resulting drug-protein complex inhibits calcineurin, a calcium-dependent phosphatase transmitting chemical that in turn decreases the activity of T-lymphocytes in the immune system.

Uses: This mentioned medication is indicated with other medication to prevent rejection of a kidney, heart, or liver transplant. Tacrolimus belongs to a class of drugs known as immunosuppressants that weakens the body's defense system to help the body accept the new organ as if it were its own.

Popular Brands and Dosages: Given Immunosuppressant medication is used as the main active component in a popular brand medicine as follows:

  • Prograf: 0.5 mg and 5 mg

This medication shall be consumed exactly as prescribed by the doctor. Before consuming this drug, the medical history must be discussed with the doctor.