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Lubiprostone medication is a chloride channel activator. It is an activator of chloride channels in the intestine that treats chronic constipation and irritable bowel syndrome. This medicine also used to treat idiopathic chronic constipation. It is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. This promotes the secretion of a chloride-rich fluid that softens the stool, which increases gastrointestinal motility, and induces spontaneous bowel movements.    

Class of Drugs – Chloride Channel Activators

Molecular Formula – C23H32N2O5

Molecular Weight - 416.5 g/mol

Working: The condition of chronic constipation occurs due to the slow transit of stool through the colon. It allows too much fluid to be removed from the stool that leads to hard or lumpy stools, abdominal pain or discomfort, and straining during bowel movements. It may also cause difficulty in passing stools. This medicine Lubiprostone increases the fluid in the stool. It also causes an increase in the secretion of fluid in the intestines. Due to this extra fluid softens the stool and speed up the transit of stool in the colon.

Uses: This mentioned active component Lubiprostone treats certain types of constipation i.e. chronic idiopathic constipation, irritable bowel syndrome with constipation. This medication is also used to treat constipation caused by narcotic medications in people with pain due to medical conditions except cancer. It improves the symptoms like bloating and abdominal discomfort, improves stool texture, lessen the need to strain, and decreases the feeling of not completely relieving oneself.

Popular Brands and Dosages: Given chloride channel activator medicine is used in a popular brand as mentioned below:

  • Amitiza: 8 mcg

Drink more water than usual while treating with this medication.