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Tenofovir Alafenamide

[ Generic Medicines for Liver Disease Treatment ]

Tenofovir Alafenamide is a synthetic antiviral acyclic nucleotide, which is a nucleoside reverse transcriptase inhibitor that shows antiviral activity against hepatitis B virus. It acts against human immunodeficiency virus. This medication is taken up by hepatocytes via passive diffusion and through the hepatic uptake transporters, organic anion transporting polypeptides 1B1 and 1B3. This active component incorporated into viral DNA instead of the natural substrate deoxyadenosine 5-triphosphate, and inhibits HBV reverse transcriptase, leads to DNA chain-termination and inhibition of HBV replication. It is incorporated into HIV DNA to inhibit the HIV-1 reverse transcriptase and leads to DNA chain termination and impairment of HIV replication.

Class of Drugs – Nucleoside reverse transcriptase inhibitors

Molecular Formula – C21H29N6O5P

Molecular Weight - 476.5 g/mol

Working: Given active component belongs to a class of HIV drugs known as nucleoside reverse transcriptase inhibitors. This Tenofovir Alafenamide blocks an HIV enzyme called reverse transcriptase. It acts by blocking reverse transcriptase that prevents HIV from multiplying and can decrease the amount of HIV in the body.

Uses: This active component is used in medication to treat chronic hepatitis B infection, a viral infection of the liver. Tenofovir Alafenamide works by restricting or slowing the growth of the virus. Chronic hepatitis infection can result in serious liver damage or cirrhosis and liver cancer.

It is advisable to practice safer sex to lower the risk of passing the virus to others.

Popular Brands and Dosages: This cancer drug is used in a popular brand medication as mentioned below:

  • Vemlidy: 25 mg

Before consuming this drug discuss medical history of kidney problems, HIV infection, other liver problems, bone problems, and disease of the pancreas with the doctor.