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Cilostazol

[ Generic Medicines for Intermittent Claudication Treatment ]

Cilostazol medication is a quinolinone derivative and cellular phosphodiesterase inhibitor. Specifically, for phosphodiesterase. This given drug used as active ingredient in medicines to treat intermittent claudication. It inhibits PDE activity and suppresses the cyclic adenosine monophosphate degradation. This leads to an increase in cAMP in platelets and blood vessels. This ultimately leads to inhibition of platelet aggregation and vasodilation.

Class of Drugs – An antiplatelet drug

Molecular Formula – C20H27N5O2

Molecular Weight - 369.5 g/mol

Working: The main active component Cilostazol works by reducing the pain of intermittent claudication through dilating the arteries. It improves the flow of blood and oxygen to the legs. The ingredient reduces the ability of blood to clot. It enables patients with intermittent claudication to walk longer and faster before developing pain. This medication has a unique mechanism of action than medicines pentoxifylline and the other drug approved for the same condition.

Uses: The medication is approved to improve the symptoms of a various blood flow problem in the legs i.e. intermittent claudication. It can decrease the muscle pain/cramps that may occur during exercise/walking. The condition claudication pain is caused by too little oxygen getting to the muscles.

Popular Brands and Dosages: This given drug Cilostazol is used as main active ingredient in popular brands. The brand medicine is available in dosages as mentioned below:

  • Pletal: 50 mg and 100 mg